产品展示更多>>
- AZD-9291 1421373-65-0
- AZD-9291 1421373-65-0
AZD-9291 1421373-65-0
产品描述 描述 AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 EGFR inhibitor; AZD9291; AZD 9291;Tagrisso;Osimertinib; Mereletinib外观 Powder可溶性/溶解性 DMSO ：99 mg/mL warmed (198.15 mM)
Ethanol ：43 mg/mL warmed (86.06 mM)生物活性 靶点 L858R/T790M EGFR ,Exon 19 deletion EGFR ,WT EGFRIn vitro(体外研究) AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro.In vivo(体内研究) AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo.研究领域 研究领域 CancerGrowth factorsEGFCancerOncoproteins/suppressorsOncoproteinsGrowth factor receptorsCancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinasesCancerTumor biomarkersReceptorsCell CycleCell differentiationMicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS CoronavirusNeuroscienceDevelopmentNeuroscienceProcessesSignal TransductionGrowth Factors/HormonesEGFSignal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine KinasesDrug DiscoverySmall Molecule DrugLead Compound DiscoveryAZD-9291 1421373-65-0温馨提示：本产品仅作科研实验使用，不支持临床等研究