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- IM-12 1129669-05-1
- IM-12 1129669-05-1
IM-12 1129669-05-1
产品描述 描述 The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 The GSK3β Inhibitor XIX, IM 12, IM-12,IM12外观 Powder可溶性/溶解性 Ethanol ：10 mg/mL (26.49 mM) warmed
DMSO ：70 mg/mL (185.5 mM)生物活性 靶点 GSK-3βIn vitro(体外研究) In hNPCs, IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly. Through the activation of canonical Wnt signalling pathway, IM-12 promotes the neuronal differentiation of human neural progenitor cells.研究领域 研究领域 Stem CellsSignaling PathwaysDrug DiscoverySmall Molecule DrugLead Compound DiscoveryIM-12 1129669-05-1温馨提示：本产品仅作科研实验使用，不支持临床等研究