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- LY2090314 603288-22-8
- LY2090314 603288-22-8
LY2090314 603288-22-8
产品描述 描述 LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 LY 2090314；LY-2090314外观 yellow to orange powder可溶性/溶解性 DMSO : 93 mg/mL (181.5 mM)
Ethanol : 2 mg/mL warmed (3.9 mM)生物活性 靶点 GSK-3β；GSK-3αIn vitro(体外研究) LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.In vivo(体内研究) LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts.研究领域 研究领域 Stem CellsSignaling PathwaysDrug DiscoverySmall Molecule DrugLead Compound DiscoveryLY2090314 603288-22-8温馨提示：本产品仅作科研实验使用，不支持临床等研究