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- AT13148 1056901-62-2
- AT13148 1056901-62-2
AT13148 1056901-62-2
产品描述 描述 AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 AT 13148；AT-13148可溶性/溶解性 DMSO Solubility: 62 mg/mL (197.59 mM)生物活性 靶点 PKA,ROCK2,ROCK1,p70S6K,Akt1In vitro(体外研究) AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling.In vivo(体内研究) AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts.研究领域 研究领域 EpigeneticsCancerCell DeathApoptosisMetabolismCancerSignal transductionProtein phosphorylationSerine/threonine kinasesAKTEpigeneticsCell cycleApoptosisNuclearMetabolismPathways and ProcessesMetabolism processesApoptosisSignal TransductionProtein PhosphorylationSer / Thr KinasesPKB / AKTDrug DiscoverySmall Molecule DrugLead Compound DiscoveryAT13148 1056901-62-2温馨提示：本产品仅作科研实验使用，不支持临床等研究