Gabapentin-lactam, a cell permeable compound, has been reported to reduce oxygen glucose deprivation-induced [3H]glutamate release in rat ischemia hippocampal slices. Glutamate has been an excitotoxin and its inhibition can decrease the number of surviving ganglion cells in vitro. In mechanistic studies it has been demonstrated that the neuroprotective characteristics of Gabapentin-lactam take effect via opening of ATP-sensitive potassium channels.

A potassium channel modulator and potential neuroprotector

99%

Solid

Store at room temperature

3,3-环戊烷-4-丁内酰胺; 3,3-亚戊基丁内酰胺;3,3-Pentamethylene-4-butyrolactam; 2-Azaspiro[4.5]decan-3-one

1.06 g/cm3 (Predicted)

84-89° C (lit.)

181° C at 13 mmHg

n20D 1.51 (Predicted)

Soluble in DMSO (>40 mg/ml), ethanol (>40 mg/ml), chloroform, dimethyl sulfoxide, DMF, methanol, and water (partly miscible).

MFCD00177938

47457

451-630-1