Gabaculine is a conformationally constrained analog of γ-aminobutyric acid (GABA). It acts as an irreversible and potent inhibitor of GABA transaminase, the enzyme that converts GABA in the brain into succinate semialdehyde that can enter the citric acid Gabaculine is a substrate of GABA Receptor.

A conformationally constrained analog of GABA

≥95%

Solid

Store at -20° C

203-206° C (dec.)

n20D 1.57 (Predicted)

pKa: 3.75 (Predicted), pKb: 8.86 (Predicted)

Soluble in water (25 mg/ml), DMSO, and methanol.

MFCD00036983

198382

4552667

261-802-6