E6 Berbamine is a potent, selective, cell-permeable CaM (calmodulin) antagonist which inhibits calmodulin-dependent enzymes such as MYLK (myosin light chain kinase) (IC50=8 µM) and PDE (phosphodiesterase I) (IC50=0.53 µM).

A selective and cell-permeable CaM antagonist

Store solutions at -20°C for up to 3 months.

Store at -20° C

6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate; Calmodulin inhibitor

1.26 g/cm3

n20D 1.61

MLC kinase: IC50 = 8 µM; phosphodiesterase I: IC50 = 0.53 µM; imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs: IC50 = 2.13 µM (human)

pKb: 7.69

Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)

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