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- TAE-226 761437-28-9
- TAE-226 761437-28-9
TAE-226 761437-28-9
产品描述 描述 TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 TAE226, TAE-226,TAE 226,NVPTAE226外观 Powder可溶性/溶解性 DMSO 94 mg/mL (200.45 mM)生物活性 靶点 PYK2 ,FAK ,Insulin Receptor ,IGF-1R ,c-MetIn vitro(体外研究) NVP-TAE226 ( NVP-TAE226 (5 μM) inhibits phosphorylation of FAK in the human neuroblastoma cell line SK-N-AS. NVP-TAE226 ( NVP-TAE226 (0.1 μM-10 μM) inhibits tube formation of HMEC1 cells.In vivo(体内研究) NVP-TAE226 (75 mg/kg) significantly increases the survival rate of mice bearing intracranial glioma xenografts. NVP-TAE226 (100 mg/kg, oral) exerts significant decrease in microvessel density in a human colon cancer model in SCID mice. NVP-TAE226 (100 mg/kg, oral) efficiently inhibits MIA PaCa-2 human pancreatic tumor growth without body weight loss in vivo model. NVP-TAE226 inhibits 4T1 murine breast tumor growth and metastasis to the lung in a dose-dependent manner in vivo model, associated with inhibition of FAK autophosphorylation at Y397 and Akt phosphorylation at Serine473.研究领域 研究领域 CancerCancer MetabolismResponse to hypoxiaMetabolismPathways and ProcessesMetabolism processesHypoxiaSignal TransductionProtein PhosphorylationTyrosine KinasesFAK / PYKSignal TransductionProtein PhosphorylationTyrosine KinasesOtherDrug DiscoverySmall Molecule DrugLead Compound DiscoveryTAE-226 761437-28-9温馨提示：本产品仅作科研实验使用，不支持临床等研究