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- Ki-16425 355025-24-0
- Ki-16425 355025-24-0
Ki-16425 355025-24-0
产品描述 描述 Ki-16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6.
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 Debio 0719；Ki16425外观 white powder可溶性/溶解性 DMSO : ≥ 100 mg/mL (210.54 mM)生物活性 靶点 LPL ReceptorIn vitro(体外研究) Ki-16425 (10 μM; 1.5 hours; HEK293A cells) treatment blocks LPA-induced dephosphorylation of YAP/TAZ in HEK293A cells. Ki16425 partially inhibits the ability of serum to repress YAP/TAZ phosphorylation, particularly at low serum concentrations (0.2%).In vivo(体内研究) Ki-16425 (Debio 0719) (1-30 mg/kg; i.p.; at 30 min prior to LPA injection) inhibits LPA-induced neuropathic pain-like behaviors.研究领域 研究领域 NeuroscienceDrug DiscoverySmall Molecule DrugLead Compound DiscoveryKi-16425 355025-24-0温馨提示：本产品仅作科研实验使用，不支持临床等研究