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- CI-994 112522-64-2
- CI-994 112522-64-2
CI-994 112522-64-2
产品描述 描述 CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.
纯度 >98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 乙酰地那林；Acetyldinaline; Tacedinaline; PD 123654; Goe 5549外观 off-white Powder可溶性/溶解性 DMSO : 26.9 mg/mL (100 mM)生物活性 靶点 HDAC1 ,HDAC2 ,HDAC3In vitro(体外研究) CI-994 ( CI-994 inhibits growth of LNCaP cell with IC50 of 7.4 μM. CI-994 exerts activity against several tumor cell lines with greater cytotoxicity against the solid tumors relative to both the leukemia and normal fibroblast cell lines. CI-994 inhibits growth of rat leukemia BCLO cells with IC50 of 2.5 μM.In vivo(体内研究) CI-994 exerts demonstrated antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.研究领域 研究领域 CardiovascularHeartHypertrophyOtherEpigeneticsChromatin Modifying EnzymesAcetylationEpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass IStem CellsSignaling PathwaysWntHDACsDrug DiscoverySmall Molecule DrugLead Compound DiscoveryCI-994 112522-64-2温馨提示：本产品仅作科研实验使用，不支持临床等研究