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- ReACp53
- ReACp53
产品描述 描述 ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
来源 Synthetic序列 H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.注意事项 该产品以TFA盐的形式提供基本信息 别名 RRRRRRRRRRPILTRITLE外观 White to off-white Powder可溶性/溶解性 DMSO ：10 mg/mL (3.82 mM)
Water ：100 mg/mL (38.21 mM)生物活性 靶点 p53 amyloid formationIn vitro(体外研究) ReACp53 rescues p53 transcription of target genes and restores apoptosis. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death.In vivo(体内研究) ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53.研究领域 研究领域 CancerCell cycleCell cycle inhibitorsp53 pathwayCancerOncoproteins/suppressorsTumor suppressorsp53 pathwayApoptosisIntracellularp53 PathwayCell CycleCell Cycle Inhibitorsp53EpigeneticsCell cycleCell Cycle Inhibitorsp53EpigeneticsDNA / RNADNA Damage & RepairDNA Damage Responsep53EpigeneticsTranscriptionCancer susceptibilityTumor SuppressorsNeuroscienceDevelopmentNeuroscienceProcessesDrug DiscoverySmall Molecule DrugLead Compound Discovery温馨提示：本产品仅作科研实验使用，不支持临床等研究