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- (S)-crizotinib 1374356-45-2
- (S)-crizotinib 1374356-45-2
(S)-crizotinib 1374356-45-2
产品描述 描述 (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 可溶性/溶解性 DMSO:42 mg/mL warmed (93.26 mM)生物活性 靶点 MTH1In vitro(体外研究) (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells.In vivo(体内研究) (S)-Crizotinib (50 mg/kg, orally, daily) impairs tumor growth in an SW480 colon carcinoma xenograft model.参考文献 参考文献 1. Huber KV, et al. Nature. 2014 , 508(7495), 222-227.
研究领域 研究领域 EpigeneticsDNA / RNADNA Damage & RepairBase Excision RepairDrug DiscoverySmall Molecule DrugLead Compound Discovery(S)-crizotinib 1374356-45-2温馨提示：本产品仅作科研实验使用，不支持临床等研究