CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:38 mg/mL (128.98 mM)

CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier.

CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model.