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- Domatinostat 910462-43-0
- Domatinostat 910462-43-0
Domatinostat 910462-43-0
产品描述 描述 Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 4SC-202 free base可溶性/溶解性 DMSO:89 mg/mL (198.87 mM)生物活性 靶点 HDAC3 ,HDAC2 ,HDAC1 ,HDAC11 ,HDAC5In vitro(体外研究) In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 μM. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM.In vivo(体内研究) In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model.研究领域 研究领域 CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteinsCancerOncoproteins/suppressorsTumor suppressorsOtherCardiovascularHeartHypertrophyOtherEpigeneticsChromatin Modifying EnzymesAcetylationEpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass IMetabolismTypes of diseaseCancerMetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolismStem CellsSignaling PathwaysWntHDACsDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDomatinostat 910462-43-0温馨提示：本产品仅作科研实验使用，不支持临床等研究