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- EI1 1418308-27-6
- EI1 1418308-27-6
EI1 1418308-27-6
产品描述 描述 EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 可溶性/溶解性 DMSO:42 mg/mL warmed (107.55 mM)生物活性 靶点 EZH2 (Y641F) ,Ezh2 (wild-type)In vitro(体外研究) In DLBCL cells, EI1 inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 also inhibit H3K27me3 and cell proliferation. In addition, EI1 selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.参考文献 参考文献 研究领域 研究领域 EpigeneticsDrug DiscoverySmall Molecule DrugLead Compound DiscoveryEI1 1418308-27-6温馨提示：本产品仅作科研实验使用，不支持临床等研究