产品展示更多>>
- Alvelestat 848141-11-7
- Alvelestat 848141-11-7
Alvelestat 848141-11-7
产品描述 描述 Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 AZD9668外观 White Solid可溶性/溶解性 DMSO : 40 mg/mL (73.32 mM)生物活性 靶点 neutrophil elastase ,neutrophil elastaseIn vitro(体外研究) AZD9668 inhibits plasma NE activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.In vivo(体内研究) In mice and rats, AZD9668 (p.o.) prevents human NE-induced lung injury. In a mouse model of smoke-induced airway inflammation, AZD9668 significantly reduces the number of BAL neutrophils and BAL IL-1β. In a guinea pig chronic smoke model, AZD9668 prevents airspace enlargement and small airway wall remodeling in guinea pigs in response to chronic tobacco smoke exposure.参考文献 参考文献 研究领域 研究领域 Proteolysis / UbiquitinProteasome / UbiquitinSignal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsCollagenSignal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsElastinDrug DiscoverySmall Molecule DrugLead Compound DiscoveryAlvelestat 848141-11-7温馨提示：本产品仅作科研实验使用，不支持临床等研究