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- 6-Hydroxyflavone 6665-83-4
- 6-Hydroxyflavone 6665-83-4
6-Hydroxyflavone 6665-83-4
产品描述 描述 6-Hydroxyflavone is a flavone, a type of chemical compound. It is one of the noncompetitive inhibitors of cytochrome P450 2C9. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India).[1] 6-Hydroxyflavone may have a potential as a therapeutic drug capable for the treatment of anxiety-like disorders.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 6-羟基黄酮可溶性/溶解性 10 mM in DMSO生物活性 靶点 GABAA receptorIn vitro(体外研究) 6HF binds to GABAA receptors with moderate affinity.In vivo(体内研究) In mice, 6HF exhibits anxiolytic-like effect in the elevated plus-maze test, unaccompanied at anxiolytic doses by the sedative, cognitive impairing, myorelaxant, motor incoordination and anticonvulsant effects commonly associated with classical BZs when tested in the hole-board, step-through passive avoidance, horizontal wire, rotarod, and pentylenetetrazol (PTZ)-induced seizure tests, respectively.参考文献 参考文献 1. Wang X, et al. PLoS One. 2015 Mar 19;10(3):e0116409.
2. Ren L, et al. Biochem Pharmacol. 2010 May 1;79(9):1337-44.
研究领域 研究领域 Drug DiscoverySmall Molecule DrugLead Compound Discovery6-Hydroxyflavone 6665-83-4温馨提示：本产品仅作科研实验使用，不支持临床等研究