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- Methyl Vanillate 3943-74-6
- Methyl Vanillate 3943-74-6
Methyl Vanillate 3943-74-6
产品描述 描述 Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 香草酸甲酯外观 Pale yellow to beige Powder可溶性/溶解性 DMSO : ≥ 100 mg/mL (548.94 mM)生物活性 靶点 Wnt/β-cateninIn vitro(体外研究) Methyl vanillate (MV) activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. It increases the expression of differentiation markers RUNX2, BMP2, ALP, and OCN in a dose-dependent manner. MV decreases and increases the expression of RANKL and OPG, respectively. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts.In vivo(体内研究) Methyl vanillate rescues trabecular or cortical femoral bone loss in the ovariectomized mice without inducing any significant weight changes or abnormality in liver tissue when administrated orally.参考文献 参考文献 研究领域 研究领域 ImmunologyCancerCancer MetabolismCancerTumor biomarkersCancerTumor immunologyStem CellsCancer Stem CellsDrug DiscoverySmall Molecule DrugLead Compound DiscoveryMethyl Vanillate 3943-74-6温馨提示：本产品仅作科研实验使用，不支持临床等研究