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- SL-327 305350-87-2
- SL-327 305350-87-2
SL-327 305350-87-2
产品描述 描述 SL-327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 SL327；SL 327；Mek-1/Mek-2 Inhibitor外观 white solid可溶性/溶解性 DMSO : 68 mg/mL (202.77 mM; Need ultrasonic)生物活性 靶点 MEK1；MEK2,AP-1In vitro(体外研究) SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL-327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII.In vivo(体内研究) SL-327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. SL-327 (30 mg/kg) significantly impairs spatial learning in mice. SL-327 (50 mg/kg) blocks cocaine-induced properties.研究领域 研究领域 Signal TransductionProtein PhosphorylationSer / Thr KinasesMAPK PathwaySignal TransductionProtein PhosphorylationTyrosine KinasesOtherDrug DiscoverySmall Molecule DrugLead Compound DiscoverySL-327 305350-87-2温馨提示：本产品仅作科研实验使用，不支持临床等研究