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- AG-337;Nolatrexed dihydrochloride 152946-68-4
- AG-337;Nolatrexed dihydrochloride 152946-68-4
AG-337;Nolatrexed dihydrochloride 152946-68-4
产品描述 描述 Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 盐酸诺拉曲塞；二盐酸诺拉曲塞外观 Off-White to Pale Yellow Solid可溶性/溶解性 DMSO > 10 mM参考文献 参考文献 1. Hughes AN, et al. Br J Cancer. 2000 May;82(9):1519-27.
2. Rafi I, et al. J Clin Oncol. 1998 Mar;16(3):1131-41.
研究领域 研究领域 EpigeneticsDNA / RNADNA SynthesisOtherMetabolismPathways and ProcessesMetabolic signaling pathwaysNucleotide metabolismPurine and pyrimidine synthesisDrug DiscoverySmall Molecule DrugLead Compound DiscoveryAG-337;Nolatrexed dihydrochloride 152946-68-4温馨提示：本产品仅作科研实验使用，不支持临床等研究