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- Ascomycin (FK520) 104987-12-4；11011-38-4
- Ascomycin (FK520) 104987-12-4；11011-38-4
Ascomycin (FK520) 104987-12-4；11011-38-4
产品描述 描述 Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 长川霉素；子囊霉素；Immunomycin；FR-900520；FK520外观 白色至类白色结晶性粉末可溶性/溶解性 DMSO : 39.6 mg/mL (50 mM)
Ethanol : 39.6 mg/mL (50 mM)生物活性 靶点 calcineurin phosphataseIn vitro(体外研究) Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein.In vivo(体内研究) Ascomycin (3.2 mg/kg, i.m.) clearly prolongs skin allograft survival in rats. Ascomycin, at 50 or 100 μM, produces anticonvulsant effect against picrotoxin-induced seizures when infused into the rat hippocampus.参考文献 参考文献 1. Hatanaka H, et al. J Antibiot (Tokyo). 1988, 41(11), 1592-1601.
2. Revill WP, et al. J Pharmacol Exp Ther. 2002, 302(3), 1278-1285.
研究领域 研究领域 Drug DiscoverySmall Molecule DrugLead Compound DiscoveryAscomycin (FK520) 104987-12-4；11011-38-4温馨提示：本产品仅作科研实验使用，不支持临床等研究