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- CID755673 521937-07-5
- CID755673 521937-07-5
CID755673 521937-07-5
产品描述 描述 CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 CID 755673外观 Brown powder可溶性/溶解性 DMSO : 21.7 mg/mL (100 mM)生物活性 靶点 PKD1 ,PKD3 ,PKD2In vitro(体外研究) In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport. In prostate cancer cells, CID755673 potently blocks cell migration and invasion, and also shows inhibition activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alter primary human NK cell effector functions.In vivo(体内研究) CID755673, via PKD/PKD1 inhibition, significantly ameliorates necrosis and severity of pancreatitis in a rat acute pancreatitis model.参考文献 参考文献 1. Sharlow ER, et al. J Biol Chem. 2008, 283(48), 33516-33526.
2. Yuan J, et al. Front Physiol. 2012, 3, 60.
研究领域 研究领域 CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteinsMetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolismNeuroscienceDevelopmentSignal TransductionProtein PhosphorylationSer / Thr KinasesPKCDrug DiscoverySmall Molecule DrugLead Compound DiscoveryCID755673 521937-07-5温馨提示：本产品仅作科研实验使用，不支持临床等研究