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- Bromfenac sodium hydrate 120638-55-3
- Bromfenac sodium hydrate 120638-55-3
Bromfenac sodium hydrate 120638-55-3
产品描述 描述 Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).
纯度 95%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 溴芬酸na水合物；Bromfenac monosodium salt sesquihydrate外观 黄色或橙黄色结晶性粉末可溶性/溶解性 DMSO : ≥ 36 mg/mL (93.95 mM)生物活性 靶点 COX-2参考文献 参考文献 1. Shimura M, Yasuda K. Br J Ophthalmol. 2015 Feb;99(2):215-9.
研究领域 研究领域 ImmunologyMetabolismTypes of diseaseDrug DiscoverySmall Molecule DrugLead Compound DiscoveryBromfenac sodium hydrate 120638-55-3温馨提示：本产品仅作科研实验使用，不支持临床等研究