产品展示更多>>
- Cevimeline hydrochloride hemihydrate 153504-70-2
- Cevimeline hydrochloride hemihydrate 153504-70-2
Cevimeline hydrochloride hemihydrate 153504-70-2
产品描述 描述 Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 盐酸西维美林半水合物；SNI-2011；AF102B hydrochloride hemihydrate外观 white to tan powder可溶性/溶解性 H2O : ≥ 50 mg/mL (204.27 mM)生物活性 In vitro(体外研究) In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.In vivo(体内研究) Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.研究领域 研究领域 NeuroscienceDrug DiscoverySmall Molecule DrugLead Compound DiscoveryCevimeline hydrochloride hemihydrate 153504-70-2温馨提示：本产品仅作科研实验使用，不支持临床等研究