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- Acotiamide hydrochloride hydrate 773092-05-0
- Acotiamide hydrochloride hydrate 773092-05-0
Acotiamide hydrochloride hydrate 773092-05-0
产品描述 描述 Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 盐酸阿考替胺三水合物可溶性/溶解性 10 mM in DMSO生物活性 In vitro(体外研究) Acotiamide inhibits AChE with half maximal inhibitory concentrations (IC50) of 3.0, 2.3 and 1.2 μM for human recombinant, and rat and canine gastric AChEs, respectively.In vivo(体内研究) Acotiamide is concentrated into the stomach tissue by carrier-mediated uptake processes, which may account for the selective action of acotiamide for gastric smooth muscle but not for skeletal muscle and central nervous system in rats.参考文献 参考文献 1. Kawachi M,et al. Eur J Pharmacol. 2011 Sep;666(1-3):218-25.
研究领域 研究领域 ImmunologyMetabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryAcotiamide hydrochloride hydrate 773092-05-0温馨提示：本产品仅作科研实验使用，不支持临床等研究