＞98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

HS 173；HS173

Grey to Brown Powder

DMSO : 78 mg/mL (184.6 mM)

PI3Kα

HS-173 shows potent antiproliferative effects in T47D, SK-BR3, and MCF7 cells with IC50 of 0.6, 1.5, and 7.8 μM, respectively. HS-173 causes complete suppression of the PI3K pathway in cancer cell lines (Hep3B and SkBr3). Moreover, HS-173 induces cell apoptosis by affecting cell-cycle distribution and activating caspases, and block VEGF-induced angiogenesis in vitro. Combined treatment with Sorafenib and HS-173 has a synergistic anti-cancer effect on pancreatic cancer cells.

HS-173 diminishes blood vessel formation in mice. HS-173 markedly attenuates the development of liver fibrosis by blocking PI3K/Akt signaling in vivo.