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- Terconazole 67915-31-5

- Terconazole 67915-31-5
Terconazole 67915-31-5
产品描述 描述 Arecoline is a muscarinic acetylcholine receptor agonist. Arecoline induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells.纯度 ≥98%储存/保存方法 Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.基本信息 别名 特康唑;曲康唑;R42470外观 white powder可溶性/溶解性 DMSO : ≥ 30 mg/mL (56.34 mM)生物活性 In vitro(体外研究) Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL.In vivo(体内研究) A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole.参考文献 参考文献 研究领域 研究领域 MetabolismTypes of diseaseDrug DiscoverySmall Molecule DrugLead Compound DiscoveryTerconazole 67915-31-5温馨提示:本产品仅作科研实验使用,不支持临床等研究
