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- Diaveridine 5355-16-8
- Diaveridine 5355-16-8
Diaveridine 5355-16-8
产品描述 描述 Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify this.[1]
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 敌菌净；二氨藜芦啶；EGIS-5645外观 白色或淡黄色结晶性粉末可溶性/溶解性 DMSO : 32 mg/mL (122.94 mM; Need ultrasonic)生物活性 靶点 DHFRIn vitro(体外研究) Diaveridine (DVD) is a pyrimethamine analogue, a folic acid antagonist. It is also used as an antibacterial agent, especially for the respiratory and gastrointestinal tract infections in humans and animals. Diaveridine is genotoxic in mammalian cells in vitro and in vivo.In vivo(体内研究) Acute tests indicate that the diaveridine has a high LD50 value and suggests a wide margin of safety for therapeutic doses.参考文献 参考文献 1. Ono T, et al. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306.
2. Carroll PT, et al. Invest Urol. 1971 May;8(6):686-94.
研究领域 研究领域 Signal TransductionMetabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDiaveridine 5355-16-8温馨提示：本产品仅作科研实验使用，不支持临床等研究