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- L-779450 303727-31-3
- L-779450 303727-31-3
L-779450 303727-31-3
产品描述 描述 L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 L-779,450；4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑外观 Beige solid可溶性/溶解性 DMSO : 34 mg/mL参考文献 参考文献 1. Shelton JG, et al. Leukemia. 2003 Sep;17(9):1765-82.
2. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.
研究领域 研究领域 CancerOncoproteins/suppressorsOncoproteinsSignal transducersApoptosisIntracellularKinasesCell CycleCell differentiationSignal TransductionProtein PhosphorylationSer / Thr KinasesOther KinasesSignal TransductionProtein PhosphorylationTyrosine KinasesOtherDrug DiscoverySmall Molecule DrugLead Compound DiscoveryL-779450 303727-31-3温馨提示：本产品仅作科研实验使用，不支持临床等研究