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- P7C3 301353-96-8
- P7C3 301353-96-8
P7C3 301353-96-8
产品描述 描述 The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol外观 white to off-white可溶性/溶解性 DMSO : 88 mg/mL (185.6 mM)
Ethanol : 16 mg/mL (33.7 mM)生物活性 靶点 NAMPTIn vitro(体外研究) In U2OS Cells, P7C3 protects cells from doxorubicin-mediated toxicity, and enhances the flux of nicotinamide through the NAMPT-mediated salvage pathway.In vivo(体内研究) In mouse brain, P7C3 (40 mg/kg, p.o.) induces neurogenesis and enhances survival of newborn neurons. In npas3−/− mice, P7C3 (20 mg/kg/d, p.o.) increases the magnitude of neural precursor cell proliferation, and corrects morphological and electrophysiological deficits. In the Ts65Dn mouse model of Down Syndrome, P7C3 restores hippocampal neurogenesis though a significant increase in total Ki67+, DCX+, and surviving BrdU+ cells.参考文献 参考文献 1. Yin TC, et al. Cell Rep. 2014 Sep 25;8(6): 1731-40.
2. Walker AK, et al. Mol Psychiatry. 2015 Apr; 20(4): 500-8.
研究领域 研究领域 Signal TransductionMetabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryP7C3 301353-96-8温馨提示：本产品仅作科研实验使用，不支持临床等研究