- Drospirenone 67392-87-4
- Drospirenone 67392-87-4
Drospirenone 67392-87-4
产品描述 描述 Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 屈螺酮；Dihydrospirorenone外观 白色至类白色结晶粉末可溶性/溶解性 DMSO : 68 mg/mL (185.5 mM)
Ethanol : 9 mg/mL (24.6 mM)生物活性 靶点 Progesterone Receptor参考文献 参考文献 1. Bray JD, et al. J Steroid Biochem Mol Biol. 2005 Dec;97(4):328-41.
2. Maia H Jr, et al. Eur J Contracept Reprod Health Care. 2010 Feb;15(1):35-40.
3. Fuhrmann U, et al. Contraception. 1996 Oct;54(4):243-51.
4. Koitka M, et al. J Pharm Biomed Anal. 2010 Feb 5;51(3):664-78.
5. Arias-Loza PA, et al. Hypertension. 2006 Nov;48(5):994-1001.
研究领域 研究领域 CancerSignal transductionNuclear signalingNuclear hormone receptorsProgesteroneCancerTumor biomarkersReceptorsEpigeneticsNuclear Signaling PathwaysNuclear ReceptorsProgesteroneEpigeneticsTranscriptionDomain FamiliesZinc FingerNeuroscienceDevelopmentNeuroscienceProcessesNeuroscienceEndocrine systemGonadotrophic axisSignal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsProgesteroneDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDrospirenone 67392-87-4温馨提示：本产品仅作科研实验使用，不支持临床等研究