- Doxepin Hydrochloride 1229-29-4
- Doxepin Hydrochloride 1229-29-4
Doxepin Hydrochloride 1229-29-4
产品描述 描述 Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 盐酸duo塞平外观 白色粉末可溶性/溶解性 DMSO : ≥ 100 mg/mL (316.62 mM)
H2O : ≥ 50 mg/mL (158.31 mM)生物活性 靶点 Serotonin TransporterIn vitro(体外研究) Doxepin inhibits the reuptake of serotonin and norepinephrine. Its actions of the reuptake of dopamine are negligible. Doxepin also has antagonistic effects at a variety of receptors including receptors of H1, H2, 5-HT1, 5-HT2, α1-adrenergic and mACh.参考文献 参考文献 1. Ehlert FJ, et al. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9.
2. Tatsumi M, et al. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58.
3. Figueiredo A, et al. Fundam Clin Pharmacol. 1990;4(2):147-58.
4. Stahl SM, et al. CNS Spectr. 2008 Dec;13(12):1027-38.
5. Cusack B, et al. Psychopharmacology (Berl). 1994 May;114(4):559-65.
研究领域 研究领域 CancerCancer MetabolismCancerTumor immunologyDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDoxepin Hydrochloride 1229-29-4温馨提示：本产品仅作科研实验使用，不支持临床等研究