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- Cisapride 81098-60-4
- Cisapride 81098-60-4
Cisapride 81098-60-4
产品描述 描述 Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 西sha必利；R 51619；(±)-Cisaprid外观 白色固体可溶性/溶解性 10 mM in DMSO生物活性 靶点 hERG channel ,5-HT4 receptorIn vitro(体外研究) Cisapride is a 5-HT4 receptor agonist, also a hERG blockers. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist.参考文献 参考文献 1. Nagakura Y, et al. Pharmacol Res. 1999 May;39(5):375-82.
2. Walker BD, et al. Br J Pharmacol. 1999 Sep;128(2):444-50.
3. Rahme MM, et al. Circulation. 1999 Nov 9;100(19):2010-7.
4. Chen J, et al. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12461-6.
5. Haga N, et al. Neurogastroenterol Motil. 1998 Aug;10(4):295-303.
研究领域 研究领域 MetabolismTypes of diseaseObesityNeuroscienceProcessesNeuroscienceNeurology processMetabolismNeuroscienceNeurotransmissionReceptors / ChannelsGPCRSerotonin ReceptorsSignal TransductionSignaling PathwayG Protein SignalingGPCRDrug DiscoverySmall Molecule DrugLead Compound DiscoveryCisapride 81098-60-4温馨提示：本产品仅作科研实验使用，不支持临床等研究