产品展示更多>>
- Fenofibrate 49562-28-9
- Fenofibrate 49562-28-9
Fenofibrate 49562-28-9
产品描述 描述 Fenofibrate is a Peroxisome Proliferator Receptor alpha Agonist. The mechanism of action of fenofibrate is as a Peroxisome Proliferator-activated Receptor alpha Agonist. The chemical classification of fenofibrate is PPAR alpha.
纯度 98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 fei诺贝特外观 白色或类白色结晶性粉末可溶性/溶解性 DMSO : 36.1 mg/mL (100 mM)
Ethanol : 36.1 mg/mL (100 mM)生物活性 靶点 Cytochrome P450In vivo(体内研究) Daily intake of Fenofibrate at this low dose (10 μg/g/day) inhibits retinal and choroidal neovascularization induced by CYP2C8 overexpression by 29% (P=0.021) and 36% (P=1.2×10−9) respectively.参考文献 参考文献 1. Clavey V, et al. Cell Physiol Biochem. 1999;9(3):139-49.
2. Walsky RL, et al. J Clin Pharmacol. 2005 Jan;45(1):68-78.
3. Casas F, et al. FEBS Lett. 2000 Sep 29;482(1-2):71-4.
4. Bouly M, et al. J Biol Chem. 2001 Jul 13;276(28):25841-7.
研究领域 研究领域 CardiovascularLipids / LipoproteinsLipid MetabolismCytochromesMetabolismPathways and ProcessesMetabolic signaling pathwaysDrug metabolismMetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipasesMetabolismPathways and ProcessesMitochondrial MetabolismCytochromesNeuroscienceDevelopmentNeuroscienceProcessesSignal TransductionMetabolismDrug metabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryFenofibrate 49562-28-9温馨提示：本产品仅作科研实验使用，不支持临床等研究