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- Dacarbazine 4342-03-4
- Dacarbazine 4342-03-4
Dacarbazine 4342-03-4
产品描述 描述 Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 达ka巴嗪；Imidazole Carboxamide外观 微黄色结晶或粉末可溶性/溶解性 DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming)生物活性 靶点 DNA polymerase betaIn vitro(体外研究) Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway.In vivo(体内研究) Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice.参考文献 参考文献 1. Lonn U, Lohn S. Cancer Res. 1987 Jan 1;47(1):26-30.
2. Wiedemann GJ, et al. Eur J Cancer. 1996 May;32A(5):888-92.
研究领域 研究领域 CancerCancer MetabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDacarbazine 4342-03-4温馨提示：本产品仅作科研实验使用，不支持临床等研究