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- Sparfloxacin 110871-86-8
- Sparfloxacin 110871-86-8
Sparfloxacin 110871-86-8
产品描述 描述 Sparfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 司帕sha星外观 黄色结晶性粉末可溶性/溶解性 DMSO : 9 mg/mL (22.93 mM)生物活性 In vitro(体外研究) Sparfloxacin shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella . Sparfloxacin targets DNA gyrase and inhibits DNA synthesis.In vivo(体内研究) Sparfloxacin showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice.参考文献 参考文献 1. Schmitz FJ, et al. J Antimicrob Chemother. 1998 Apr;41(4):481-4.
2. Ohashi R, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84.
3. Oyamada Y, et al. J Med Microbiol. 2006 Jun; 55(Pt 6):729-36.
4. Pan XS, et al. Antimicrob Agents Chemother. 2001 Nov; 45(11):3140-7.
研究领域 研究领域 Drug DiscoverySmall Molecule DrugLead Compound DiscoverySparfloxacin 110871-86-8温馨提示：本产品仅作科研实验使用，不支持临床等研究