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- Cephalexin 15686-71-2

- Cephalexin 15686-71-2
Cephalexin 15686-71-2
产品描述 描述 Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
纯度 >98%储存/保存方法 Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.基本信息 别名 tou孢氨苄;Cefalexin;Cephacillin外观 白色或微黄色结晶性粉末可溶性/溶解性 DMSO : 2 mg/mL (5.75 mM)
Water :10 mg/mL (28.78 mM)生物活性 In vitro(体外研究) Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells.In vivo(体内研究) Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs.参考文献 参考文献 1. Williamson R, et al. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.
2. Ganapathy ME, et al. J Biol Chem. 2000 Jan 21;275(3):1699-707
3. Mitsuoka K, et al. Drug Metab Dispos. 2007 Mar;35(3):356-62.
研究领域 研究领域 MetabolismTypes of diseaseDrug DiscoverySmall Molecule DrugLead Compound DiscoveryCephalexin 15686-71-2温馨提示:本产品仅作科研实验使用,不支持临床等研究
