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- Desipramine hydrochloride 58-28-6
- Desipramine hydrochloride 58-28-6
Desipramine hydrochloride 58-28-6
产品描述 描述 Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 盐酸去甲咪嗪外观 white to off-white powder可溶性/溶解性 DMSO : 83.3 mg/mL (275.06 mM; Need ultrasonic and warming)生物活性 靶点 5-HT ReceptorIn vivo(体内研究) Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p(3,16)=4.34, p.参考文献 参考文献 1. Zavosh A, et al. Brain Res Bull. 1999 Jul 1;49(4):291-5.
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4. Matsumoto K, et al. Pharmacol Biochem Behav. 1994 Sep;49(1):13-8.
研究领域 研究领域 MetabolismTypes of diseaseObesityNeuroscienceProcessesNeuroscienceNeurology processMetabolismNeuroscienceNeurotransmissionReceptors / ChannelsGPCRSerotonin ReceptorsSignal TransductionSignaling PathwayG Protein SignalingGPCRDrug DiscoverySmall Molecule DrugLead Compound DiscoveryDesipramine hydrochloride 58-28-6温馨提示：本产品仅作科研实验使用，不支持临床等研究