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- Trimetazidine dihydrochloride 13171-25-0
- Trimetazidine dihydrochloride 13171-25-0
Trimetazidine dihydrochloride 13171-25-0
产品描述 描述 Trimetazidine dihydrochloride is a drug for angina pectoris. Trimetazidine is the first cytoprotective anti-ischemic agent , which improves myocardial glucose utilization through inhibition of fatty acid metabolism.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 yan酸曲美他嗪外观 白色至淡黄色固体可溶性/溶解性 DMSO : 67 mg/mL (197.49 mM)
Water : 67 mg/mL (197.49 mM)
Ethanol : 67 mg/mL (197.49 mM)生物活性 靶点 mitochondrial long-chain 3-ketoacyl thiolaseIn vitro(体外研究) Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion.In vivo(体内研究) The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia.参考文献 参考文献 1. Kantor PF, et al. Circ Res. 2000 Mar 17;86(5):580-8.
2. Stanley WC, Marzilli M. Fundam Clin Pharmacol. 2003 Apr;17(2):133-45.
3. Sellier P, Broustet JP. Am J Cardiovasc Drugs. 2003;3(5):361-9.
研究领域 研究领域 CardiovascularDrug DiscoverySmall Molecule DrugLead Compound DiscoveryTrimetazidine dihydrochloride 13171-25-0温馨提示：本产品仅作科研实验使用，不支持临床等研究