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- Chloroambucil 305-03-3
- Chloroambucil 305-03-3
Chloroambucil 305-03-3
产品描述 描述 Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 苯丁酸氮芥；CB-1348；WR-139013外观 类白色结晶性粉末可溶性/溶解性 DMSO : 56 mg/mL (184.1 mM)
Ethanol : 56 mg/mL (184.1 mM)生物活性 靶点 DNA AlkylatorIn vitro(体外研究) Chlorambucil can deprive the function of complementary strands of DNA molecules via alkalization-induced cross interaction, and then inhibits tumor cell proliferation. Chlorambucil (0, 2.5, 5, 10 μM) exhibits slight inhibitory effect on Raji cell apoptosis, but potently increases DR4 and DR5 mRNA expression in Raji cells. Chlorambucil (10 μM) in combination with Tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL, 80 ng/ml) has synergistic effect on Raji cell apoptosis and inhibition on proliferation.In vivo(体内研究) Chlorambucil (0.2 mg/kg, p.o.) in combination with levamisole (5 mg/kg) has enhanced anti-cancer effect on Ehrlich ascites carcinoma which elevates apoptosis of Ehrlich ascites carcinoma and the survival rate of the mice. However, Chlorambucil exhibits adverse effects on the liver and kidneys of mice.参考文献 参考文献 1. Kashiwazaki G, et al. Bioorg Med Chem. 2010 Apr 15;18(8):2887-93.
2. Bielawska A, et al. Farmaco. 2004 Feb;59(2):111-7.
研究领域 研究领域 Drug DiscoverySmall Molecule DrugLead Compound DiscoveryChloroambucil 305-03-3温馨提示：本产品仅作科研实验使用，不支持临床等研究