- Homotaurine 3687-18-1
- Homotaurine 3687-18-1
Homotaurine 3687-18-1
产品描述 描述 Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 3-氨基丙烷磺酸； Homotaurine；3-Amino-1-propanesulfonic acid外观 白色结晶性粉末可溶性/溶解性 H2O : 20 mg/mL (143.71 mM; Need ultrasonic)
DMSO : 1 mg/mL (7.19 mM; Need ultrasonic)生物活性 靶点 Amyloid-(beta)参考文献 参考文献 1. Fariello RG, et al. Neurology, 1982, 32 (3): 241–5.
2. Fariello RG, et al. Neurology, 1982, 32 (3): 241–6.
3. Gauthier, S, et al. The journal of nutrition, health & aging, 2009, 13 (6): 550–7.
4. Gauthier, S, et al. The journal of nutrition, health & aging, 2009, 13 (6): 550–8.
5. Aisen PS, et al. Curr Alzheimer Res, 2007, 4 (4): 473–8.
研究领域 研究领域 CancerCancer MetabolismDrug DiscoverySmall Molecule DrugLead Compound DiscoveryHomotaurine 3687-18-1温馨提示：本产品仅作科研实验使用，不支持临床等研究