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- Tryptamine 61-54-1
- Tryptamine 61-54-1
Tryptamine 61-54-1
产品描述 描述 Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It contains an indole ring structure, and is structurally similar to the amino acid tryptophan, from which it derives its name. Tryptamine is found in trace amounts in the brains of mammals and is believed to play a role as a neuromodulator or neurotransmitter.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 色胺外观 类白色粉末可溶性/溶解性 DMSO : ≥ 150 mg/mL (936.21 mM)生物活性 靶点 hTAAR1In vitro(体外研究) High concentrations of tryptamine (0.1-1 mM) induce autophagy in HT22 and SK-N-SH nerve cell lines and in primary cultures of astrocytes, glial cells being less sensitive than neurons.In vivo(体内研究) Tryptamine at a dose of 50 mg/kg i.p. induces an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induces peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. Tryptamine induces both the depression and excitation in the behavior of mice depending on the dosage and Tryptamine-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release.参考文献 参考文献 1. Berman HM, et al. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2. Zhang Z, et al. Biosens Bioelectron. 2014 Oct 15;60:161-6.
3. Paley EL, et al. Curr Alzheimer Res. 2013 Nov;10(9):987-1004.
研究领域 研究领域 Drug DiscoverySmall Molecule DrugLead Compound DiscoveryTryptamine 61-54-1温馨提示：本产品仅作科研实验使用，不支持临床等研究