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- Oxybenzone 131-57-7
- Oxybenzone 131-57-7
Oxybenzone 131-57-7
产品描述 描述 Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
纯度 99%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 氧苯酮；Benzophenone 3外观 白色至淡黄色结晶性粉末可溶性/溶解性 Water : 69 mg/L
Ethanol : 45 mg/mL (197.16 mM) .生物活性 In vitro(体外研究) A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochromeP450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure.In vivo(体内研究) In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver (.参考文献 参考文献 1. Gonzalez H, et al. Br J Dermatol. 2006 Feb;154(2):337-40.
2. Pawar AP, et al. J Drug Deliv. 2015;2015:261068.
研究领域 研究领域 NeuroscienceDrug DiscoverySmall Molecule DrugLead Compound DiscoveryOxybenzone 131-57-7温馨提示：本产品仅作科研实验使用，不支持临床等研究