产品展示更多>>
- Flutamide 13311-84-7
- Flutamide 13311-84-7
Flutamide 13311-84-7
产品描述 描述 Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 氟ta胺；SCH 13521外观 淡黄色结晶性粉末可溶性/溶解性 DMSO : 51 mg/mL (184.6 mM)
Ethanol : 51 mg/mL (184.6 mM)生物活性 靶点 Androgen ReceptorIn vitro(体外研究) Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.In vivo(体内研究) Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.参考文献 参考文献 1. Chang HC, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11173-7.
2. Pazos F, et al. Pediatr Res. 2000 Jul;48(1):96-103.
3. Shilling AD, Williams DE. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):187-94.
研究领域 研究领域 CancerSignal transductionNuclear signalingNuclear hormone receptorsOtherDevelopmental BiologyReproductionHormonesEpigeneticsNuclear Signaling PathwaysNuclear ReceptorsTestosteroneNeuroscienceDevelopmentNeuroscienceProcessesSignal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsTestosteroneDrug DiscoverySmall Molecule DrugLead Compound DiscoveryFlutamide 13311-84-7温馨提示：本产品仅作科研实验使用，不支持临床等研究