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- Nitroxoline 4008-48-4
- Nitroxoline 4008-48-4
Nitroxoline 4008-48-4
产品描述 描述 Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
纯度 ＞98%储存/保存方法 Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.基本信息 别名 硝羟喹啉；5-硝基-8-羟基喹啉；8-Hydroxy-5-nitroquinoline；5-Nitro-8-quinolinol外观 桔黄色至褐黄色结晶粉末可溶性/溶解性 DMSO : 36 mg/mL (189.3 mM)生物活性 靶点 cathepsin BIn vitro(体外研究) Nitroxoline significantly reduces extracellular DQ-collagen IV degradation by all evaluated cancer cell lines using spectrofluorimetry. Nitroxoline also markedly decreases tumor cell invasion monitored in real time and reduces the invasive growth of multicellular tumor spheroids, used as a 3D in vitromodel of tumor invasion. Endothelial tube formation is significantly reduced by nitroxoline in an in vitro angiogenesis assay.In vivo(体内研究) Nitroxoline significantly abrogates tumor growth, angiogenesis and metastasis in vivo in LPB fibrosarcoma and MMTV-PyMT breast cancer mouse models.参考文献 参考文献 2. Pelletier C, et al. Antimicrob Agents Chemother. 1995 Mar;39(3):707-13.
1. Chang WL, et al. Oncotarget. 2015 Nov 24;6(37):39806-20.
1. Chang WL, et al. Oncotarget. 2015 Nov 24;6(37):39806-20.
1. Chang WL, et al. Oncotarget. 2015 Nov 24;6(37):39806-20.
研究领域 研究领域 CancerCancer MetabolismCancerTumor immunologyMetabolismTypes of diseaseDrug DiscoverySmall Molecule DrugLead Compound DiscoveryNitroxoline 4008-48-4温馨提示：本产品仅作科研实验使用，不支持临床等研究